Meprobamate high and abuse

Meprobamate high

Meprobamate high and abuse causes increases in concentration of the drug in body which leads to the following:

  • Drowsiness,
  • Sluggishness,
  • Unresponsiveness,
  • Coma,
  • Loss of muscle control,
  • Severe impairment or cessation of breathing,
  • Shock.

Meprobamate high is still a continuing problem in many countries where this drug might be available illegally.
Meprobamate is a Schedule IV drug in the USA and a S5 category drug in South Africa.

Death occurs in concentration as less as 12 g of meprobamate and survival with as much as 40 g.

Meprobamate high and abuseIn an overdose, meprobamate tablets may form a gastric bezoar, requiring physical removal of the undissolved mass of tablets through an endoscope.

Therefore, administration of activated charcoal should be considered even after 4 or if levels are rising.

Regular use for Meprobamate high can cause physical dependence and a potentially life threatening abstinence syndrome similar to that of barbiturates and alcohol which is delerium tremens.

Meprobamate with analgesics like paracetamol can induce severe liver toxicity resulting in paracetamol poisoning.

The exact form of the preparation used should be identified immediately if possible, as patients who have also overdosed on paracetamol can reduce to avoid permanent liver damage with the administration of acetylcysteine.

This Meprobamate abuse is the reason it should be discontinued as soon as possible. This is often achieved through an extended regimen of slowly decreasing doses over a period of weeks or even months.

The patient may be given a longer-acting gabanergic agent such as diazepam, in a manner similar to the use of methadone therapy for opiate addiction, before attempting de-titration.

Death of Bruce Lee is believed to have caused due to acute cerebral edema caused by a reaction to Equagesic, a type of aspirin meprobamate combination.

European Medicines Agency issued a recommendation to stop any marketing of meprobamate containing medicine and its combinations in the European Union in January 2012

Recent studies have questioned the risk of Meprobamate high abuse being more than the benefit dervived by the treatment using it.


Aspirin Mepobramate Combinations – Equagesic

Aspirin Mepobramate Combinations

Equagesic and other aspirin mepobramate combinations were once common in use as painkillers. They are used as sedatives and pain killers. These have a combination of different doses of Aspirin and meprobamate.

Bruce Lee the famous martial arts artist and actor was believed to have died by edema developing in the brain after a reaction to Equagesic, according to the coroner examination.

The most commonly used trade name of aspirin mepobramate combinations is Equagesic. The drug is indicated for short term pain treatment accompanied by tension or anxiety in patients with musculoskeletal disorders or tension headache.

aspirin mepobramate combinationsEquagesic is now not used in the United States because of its toxicity and since other more powerful, potent and specific pain killers are now available.

These pain killers unlike aspirin mepobramate combinations don’t have any sedating properties or abuse potential.

This combination was used in pains due to muscle spasms and back aches. This is because it not only had analgesic effect but also the muscle relaxing property of meprobamate.

Reason for discontinuation

One of the reasons why this combination fell out of favor of medical community is that it was more toxic than benzodiazepines, which were also useful as a mild muscle relaxant.

Meprobamate is classified as a Schedule 4 controlled substance under the Controlled Substance Act (CSA).

They are more physically sedating and mind numbing. Meprobamate, sold most commonly under the trade name Milltown which was used for its minor tranquilizing effect in 1950’s.

The incidence of increasing number of cases of abuse of meprobamate and its combinations raised concerns to make these drugs more controlled. Later on these were even banned in some countries of the world.

Due to the highly sedating nature and mind-numbing effects, the use of meprobamate and its combinations like aspirin mepobramate combination dropped greatly when valium, the first benzodiazepine was introduced into the market and began its distribution..





Meprobamate soma – Carisoprodol

Meprobamate soma

Meprobamate soma is a prodrug which is pharmacologically and structurally related to meprobamate. It is a trade name of Carisoprodol. Meprobamate soma is a skeletal muscle relaxant which is centrally acting.

Carisoprodol is metabolized into meprobamate which is a barbiturate-like drug used for the treatment of anxiety. Read more about mebrobamate here.

Meda Pharmaceuticals is the principle manufacturer and marketer of this drug in the US. The medicine is very cheap and the total cost for a complete course with Meprobamate soma is about 25$ only.

It has been banned in a few countries because of its potential for abuse and its side effects.

Its possibility and capability of being used abused as an addiction were studied in somewhat detail by a study in Norway.

Chemical structure of Meprobamate soma

IUPAC name is the following –
(RS)-2-{[(aminocarbonyl)oxy]methyl}-2-methylpentyl isopropylcarbamate

meprobamate soma structureChemical formula

The chemical formula of Meprobamate soma is C12H24N2O4

Therapeutic uses of Meprobamate soma

The following the the different uses of this medicine:

  • Analgesic action
  • Euohoric feeling
  • Help in sleeping
  • Anti anxietic
  • Helps in Muscle relaxation
  • Sleepiness

Meprobamate soma side effects

Mild side effects

Mild side effects of this drug include the following:

  • Somnolence
  • Euphoria- if it occurs it is only for a short period of time
  • Dysphoria

These side effects occur dose of 350mg is taken which is the usual dose. The medication is well tolerated and adverse effects do not occur in the majority of patients.

Moderate side effects

In some patients carisoprodol can have sedative side effects and can impair the patient’s ability to operate a motor vehicles and other machinery of various types, especially when taken with medications containing alcohol.

The intensity of the side effects of carisoprodol tends to lessen as therapy continues.

Severe side effects

  • Lack of response to stimuli,
  • Excessive sedation,
  • Severe ataxia,
  • Amnesia,
  • Confusion,
  • Agitation,
  • Intoxication.

Due to its side effects it should not be use in elderly people.

Meprobamate soma drug interactions

The interaction of carisoprodol can occur with essentially all opioids, and other centrally acting analgesics.

Interaction with codeine derived subgroup of the semi synthetic class like codeine, ethylmorphine, dihydrocodeine, hydrocodone, oxycodone, nicocodeine, benzylmorphine, the various acetylated codeine derivatives including acetyldihydrocodeine, dihydroisocodeine, nicodicodeine and others, is also known to be dangerous.

Hence, it is mandatory to  use of a smaller dose of the opioid to have a given effect. This is useful in general pains and especially where skeletal muscle injury and/or spasm is a large part of the problem.

The potentiation effect is also useful in other pain situations and is also especially useful with opioids of the open-chain class, such as methadone, levomethadone, ketobemidone, phenadoxone and others.

Deaths have resulted from carelessly combining overdoses of hydrocodone and carisoprodol.

Meprobamate soma and other muscle-relaxing drugs often were subjects of misuse in the 1950s and 1960s.
Overdose cases were reported as early as 1957.

Meprobamate soma overdose

Carisoprodol Overdose symptoms consist of the following:

  • Lack of response to stimuli,
  • Excessive sedation,
  • Severe ataxia,
  • Amnesia,
  • Confusion,
  • Agitation,
  • Intoxication,
  • Inappropriate behavioral changes.

In severe overdose

  • Respiratory depression,
  • Pulmonary aspiration,
  • Coma,
  • Death.

Overdose symptoms in combination with opiates are similar but are distinguished by the presentation of normal or pinpoint pupils, which are generally unresponsive to light.

Other resources:

Bramness JG, Furu K, Engeland A (2007). “Carisoprodol use and abuse in Norway. A pharmacoepidemiological study”. Br J Clin Pharmacol. 64 (2): 210–218. PMC 2000626. PMID 17298482.

Carisoprodol is particularly dangerous in combination with alcohol.

Flumazenil (the benzodiazepine antidote) is not effective in the management of carisoprodol overdose as meprobamate soma acts at the barbiturate binding site.


Meprobamate brand names

Meprobamate brand names

The following is the comprehensive list of Meprobamate brand names.

It is commercially available throughout the world as one of the following brands.


  • Meprobamate brand namesMeprobamate [USAN:BAN:INN:JAN]
  • MeprobamateMeprobamate brand names
  • Meprobamato
  • Miltown
  • Meprobamate and Aspirin Tablets
  • Zirpon
  • Wyseals
  • Wardamate
  • Vistabamate
  • Vio-Bamate
  • Urbilat
  • Urbil
  • Trelmar
  • Tranquisan
  • Tranquinol
  • Tranquilsan
  • Tranquillin
  • Tranquiline
  • Tranquilate
  • Tranquilan
  • Tranquil
  • Tranmep
  • Tranlisant
  • Trankvilan
  • Trancot
  • Tensonal
  • Tensol
  • Tamate
  • Stensolo
  • Spantran
  • Sowell
  • Solevione anastress
  • SK-Bamate
  • Shalvaton
  • Setran
  • Seril
  • Selene
  • Sedoselecta
  • Sedoquil
  • Sedazil
  • Sedanyl
  • Sedanil
  • Sedabamate
  • Scolazil
  • Sadanyl
  • Robamate
  • Restran
  • Restinil
  • Restinal
  • Restenyl
  • Restenil
  • Reostral
  • Rastenil
  • Quivet
  • Quietidon
  • Quanil
  • Quanane
  • Quaname
  • Q-Gesic
  • Protran
  • Proquanil
  • Promato
  • Promate
  • Procarbamide
  • Procalmidol
  • Procalmadol
  • Procalmadiol
  • Probate
  • Probamyl
  • Probamato
  • Prequil
  • Placitate
  • Placidon
  • Pimal
  • Pertranquil
  • Perquietil
  • Perequil
  • Perequietil
  • Pensive
  • Paxin
  • Pathibamate
  • Pan-tranquil
  • Pankalma
  • Panediol
  • Pancalma
  • Orolevol
  • Orlevol
  • Optarket
  • Oasil
  • Neuramate
  • Nervonus
  • Nephentine
  • Neo-Tran
  • My-trans
  • Multaun
  • Morbam
  • Misedant
  • Miltwon
  • Miltuan
  • Miltrate
  • Miltown-600
  • Miltown-400
  • Miltown-200
  • Miltown 600
  • Miltown
  • Miltaun
  • Miltann
  • Miltamato
  • Milprem-400
  • Milprem-200
  • Milprem
  • Milpath
  • Micrainin
  • Metranquil
  • Metractyl
  • Mesmar
  • Meptranactylmilprem
  • Meptran
  • Meprozine
  • Meprovanmeprozine
  • Meprovan
  • Meprotil
  • Meproten
  • Meprotanum
  • Meprotan
  • Meprotabs
  • Meprospan-400
  • Meprospan-200
  • Meprospan 400
  • Meprospan 200
  • Meprospan
  • Meprosin
  • Meprosan
  • Meprosa
  • Mepronil
  • Mepron
  • Meproleaf
  • Meprol
  • Meprodiol
  • Meprodil
  • Meprocon CMC
  • Meprocon
  • Meprocompren
  • Meproban
  • Meprobamatum [INN-Latin]
  • Meprobamato [Italian]
  • Meprobamato [INN-Spanish]
  • Meprobamat [German]
  • Meprobamat
  • Meprobam
  • Mepro-Aspirin
  • Mepro-analgesic
  • Meprindon
  • Meprin
  • Mepriam
  • Mepranil
  • Meposed
  • Mepiosine
  • Mepavlon
  • Mepantin
  • Mepamtin
  • Mendel
  • Margonil
  • Mar-Bate
  • Madiol
  • Libiolan
  • Letyl
  • Lepetown
  • Lepenil
  • Larten
  • Klort
  • Kesso-Bamate
  • Kessobamate
  • Ipsotian
  • Holbamate
  • Hartol
  • Harmonin
  • Gagexyl
  • Gadexyl
  • Fas-Cile 200
  • Fas-Cile
  • Estasil
  • Erina
  • Equitar
  • Equinil
  • Equilium
  • Equazine-M
  • Equatrate
  • Equanil suspension
  • Equanil
  • Equagesic
  • Epikur
  • Epicur
  • Enorden
  • Edenal
  • Ecuanil
  • Dormabrol
  • Diveron
  • Diurnaldiverondormabrol
  • Diurnal
  • Diron
  • Dicandiol
  • Despasmol
  • Deprol
  • DEA No. 2820
  • Dapaz
  • Cyrpon
  • Cypron
  • Crestanil
  • Coprobate
  • Cirponyl
  • Cirpon
  • Carbaxin
  • Canquil-400
  • Canquil 400
  • Calmiren
  • Calmax
  • Calmadin
  • Brobamate
  • Biobamate
  • Biobamat
  • Bamo 400
  • Bamd 400
  • Bamate
  • Ayermate
  • Ayeramate
  • Auxietil
  • Atraxin
  • Ataraxine
  • Artolon
  • Arpon
  • Arcoban
  • Appetrol-Sr
  • Appetrol
  • Apo-Meprobamate
  • Apasil
  • Apascil
  • Anzil
  • Anxietil
  • Anural
  • Ansiowas
  • Ansil
  • Ansietan
  • Ansiatan
  • Aneuxral
  • Aneuxal
  • Aneusral
  • Aneurol
  • Aneural
  • Andaxin
  • Andaksin
  • Anatimon
  • Anathylmon
  • Anastress
  • Amosene
  • Amepromat
  • 3P bamate
  • Tranquilax

If any Meprobamate brand names that you know is not available in the list above, feel free to mention below in the comments and this list will be updated.